An interesting factor about uncoupling of the proton pumping and the ATP synthesis. In infants and some cold-adapted mammals, they intentionally uncouple the proton pump and ATP synthase to generate heat in their body. This works because this allows protons to reenter the matrix without passing through the ATP synthase. And with this, the movement of protons down the gradient of the mitochondria is a favorable reaction, and proceeds with a release of heat energy.
Its pretty interesting how certain mammals can do this intentional uncoupling to generate heat to keep themselves warm. Imagine if people could control this mechanism, but likely impossible. To keep yourself warm when you need it, that would be great for the winter.
